Domperidone+Esomeprazole

Molecule Description

Domperidone+Esomeprazole is a combination medicine. It is an anti-reflux medici

ne and is used to treat gastroesophageal reflux disease (GERD), which does not respond to esomeprazole medication alone. GERD is a condition in which acid from the stomach comes back up to the food pipe and causes heartburn, belching, nausea and chest pain. It works by decreasing the amount of acid produced in the stomach and improving mortality in the gut. Thus, it reduces the backflow of stomach content to the food pipe. Domperidone+Esomeprazole is available in the form of a tablet, capsule. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting this medicine.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Domperidone+Esomeprazole

Domperidone+Esomeprazole is used to treat gastrointestinal reflux disease (GERD).

Contraindications of Domperidone+Esomeprazole

When should one not use Domperidone+Esomeprazole

If you are allergic to domperidone, esomeprazole or similar medicines.
If you have severe heart problems such as congestive heart failure, heart rhythm problems, electrolyte imbalance.
If you are taking any medicine which might affect the contraction of the heart muscle (QT prolongation).
If you are suffering from liver or kidney disorder.
If you are suffering from bleeding in the digestive system.
If you have a blockage or tear in the intestines.
If you have any tumour of the pituitary gland (Prolactin pituitary tumours).
If you are taking medicines such as Nelfinavir (used in HIV infection), Clarithromycin (antibiotic), Ketoconazole (antifungal) or Verapamil (used in high blood pressure and chest pain).

Side effects of Domperidone+Esomeprazole

Common side effects of this drug are:

Headache
Dizziness
Nausea
Vomiting
Stomach pain
Diarrhoea
Dry mouth
Drowsiness

Precautions and Warnings of Domperidone+Esomeprazole

Pregnancy

Can I take domperidone+esomeprazole during pregnancy?

It is not advised to take domperidone+esomeprazole during pregnancy until it is considered essential by the doctor and potential risks justify the benefits.

Breast Feeding

Can I take domperidone+esomeprazole while breastfeeding?

Domperidone+Esomeprazole passes in the breastmilk in a small amount. Your doctor may prescribe you this medicine while you are breastfeeding, only if it is necessary. Inform your doctor if you are a nursing mother.

Driving

Can I drive if I have taken domperidone+esomeprazole?

Domperidone+Esomeprazole may make you feel dizzy or drowsy, thus you need to be cautious while driving.

Alcohol

Can I consume alcohol with domperidone+esomeprazole?

Avoid consuming alcohol with domperidone+esomeprazole, as it may worsen the side effects.

Other General Warnings

Talk to your doctor if

You have heart problems and associated symptoms like palpitations, difficulty in breathing, and unconsciousness.
You have any liver and kidney-related diseases.
You have a specific blood test (Chromogranin A).
You have a history of fractures or have osteoporosis or taking steroids.
You develop skin lesions, especially in the sun-exposed area after taking this medicine.
You experience stomach pain or indigestion, unexplained weight loss, have problems while swallowing, vomit out food or blood after taking this medicine.
You have low levels of vitamin B12. This medicine is known to reduce the absorption of vitamin B12 after long term use. Supplements may be needed.
You are taking medicines to treat HIV or apomorphine (used to treat muscle stiffness).
You experience black stools or have a stomach tumour.
You are on this medicine for long-term treatment, your blood magnesium levels may decrease. Hence, your doctor may perform regular tests for the same.
Taking this medicine for more than one year may increase the chances of developing bone fractures.
This medicine may lead to a slightly increased risk of bacterial infections due to Salmonella and Campylobacter.
Domperidone+Esomeprazole is not recommended for patients below the age of 18 years.

Mode of Action of Domperidone+Esomeprazole

How Does It Work?

A pump called the proton pump in the stomach is responsible for the flow of stomach acids.
Domperidone acts by increasing the motility of the stomach and intestines so that acid does not reflux back into the food pipe.
Esomeprazole works by binding to this proton pump in stomach cells and blocks the acid secretion.

Interactions of Domperidone+Esomeprazole

Interactions with other medicines

Some medicines can affect the way domperidone+esomeprazole works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
Domperidone+Esomeprazole should not be taken concomitantly along with medicines such as nelfinavir (used to treat HIV infection), amiodarone (used to treat muscle stiffness), clarithromycin (antibioti...
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This combination should also not be taken along with medicines used to treat heart problems (quinidine, sotalol), psychiatric illness (haloperidol, citalopram), antifungals (pentamidine), antimalarial...
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Concomitant use along with medicines used to treat psychiatric illness (diazepam), used to treat fits (phenytoin) is not recommended as it may increase the side effects of the medicines.
Medicine used to treat heart failure like digoxin may lead to toxicity when taken with domperidone+esomeprazole.
If you are taking warfarin (blood-thinner) along with this combination, caution is needed as there are chances of increased bleeding.
Medicines like Rifampicin, Methotrexate, Tacrolimus, Voriconazole, Cilostazol, Clopidogrel, Azithromycin, St John's wort, etc. should be used cautiously along with this combination.

Content Details

WRITTEN BY

Dr. Arpit Verma

MBBS, MD CCEBDM Diabetology

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: Is domperidone+esomeprazole a steroid?

A: No, domperidone+esomeprazole is not a steroid, it is an anti-reflux medicine.

Q: In which all dosage forms is domperidone+esomeprazole available?

A: Domperidone+Esomeprazole is available in the form of tablet or capsule

References

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Last Updated on: 22 Dec 2021 | 11:37 AM (IST)

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मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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